Our research addresses mechanisms by which chemicals and oxidative stress alter cellular processes to cause diseases and the way in which intervention is possible. To reach these goals, the department's laboratory is well equipped with facilities for chemical analysis including mass spectrometry (MS), atomic absorption spectrometry (AAS) and electron spin resonance (ESR), the analysis of DNA damage and for molecular biological techniques.
One major approach employed at the department of Parmacology & Toxicology is by using so-called biomarkers. Biomarkers are substances or events that can be measured in body fluids, cells or tissues and provide information about a person's exposure to carcinogens or about cellular damage caused by carcinogens and oxidative stress far earlier than the appearance of clinical disease. Furthermore, genetic polymorphisms and gene-expression profiles can help in identifying the most susceptible individuals.
below you will find the different projects we work on. Click on the title to see more information about the selected project.
Antioxidant networks in health and disease — read more »DNA damage and repair
Modulation of DNA damage and repair by Inflammation — read more »ECNIS and ECNIS2
Environmental Cancer Risk, Nutrition and Individual Susceptibility — read more »Flaviola
Targeted delivery of dietary flavanols for optimal human cell function: Effects on cardiovascular health — read more »Genetic Variation
Assessment of genetic variations as a predictor for smoking cessation and health risks. — read more »NewGeneris
NewGeneris: Newborns and Genotoxic exposure risks — read more »Transgenerational effects
Paternal and maternal exposure to genotoxins and health risks in their offspring — read more »VOCs
Characterisation and identification of volatile organic compounds in breath from patients and healthy controls — read more »