Our research addresses mechanisms by which chemicals, pharmaca and oxidative stress alter cellular processes to cause diseases and the way in which intervention is possible. To reach these goals, the department's laboratory is well equipped with facilities for chemical analysis including mass spectrometry (MS), general molecular biological techniques and the analysis of DNA damage.
One major approach employed at the department of Parmacology & Toxicology is by using so-called biomarkers. Biomarkers are substances or events that can be measured in body fluids, cells or tissues and provide information about a person's exposure to toxins or about cellular damage caused by chemicals and oxidative stress far earlier than the appearance of clinical disease. Furthermore, genetic polymorphisms and gene-expression profiles can help in identifying the most susceptible individuals.
below you will find the different themes we work on. Click on the title to see more information about the selected project.
Antioxidant networks in health and disease — read more »DNA damage and repair
Modulation of DNA damage and repair by Inflammation — read more »Genetic Variation
Assessment of genetic variations as a predictor for smoking cessation and health risks. — read more »Transgenerational effects
Paternal and maternal exposure to genotoxins and health risks in their offspring — read more »VOCs
Characterisation and identification of volatile organic compounds in breath from patients and healthy controls — read more »Environmental exposures finalized
Environmental Cancer Risk, Nutrition and Individual Susceptibility — read more »