Department of Pharmacology & Toxicology

Antioxidant networks Antioxidant networks in health and disease

​The research in this project focuses on the role of redox processes in drug toxicity and in pathologies of the lung, the cardiovascular system and the liver. Moreover, the possibilities for therapeutic intervention with antioxidants are explored. Antioxidants, which are studied, are either food-derived compounds or drugs. The research is performed on a (bio-)chemical, cellular, organ or whole animal level. Also clinical human research is performed.

Examples of ongoing studies or studies in the past are:

  • Protection against doxorubicin-induced cardiotoxicity. Doxorubicin is widely used as a antitumour agent. It major drawback it its cardiotoxicity. Flavonoids offer protection. Flavonoids are also investigated for their protection against more general cardiovascular damage and for their contribution to maintaining cardiovascular health.
  • The antioxidant network in various tissues. Many chronic diseases are associated with oxidative stress. The involvement of the antioxidant network in chronic lung diseases (e.g. COPD, interstitial lung disease) or liver diseases (e.g. NASH) is investigated.
  • The role of oxygen radicals in fibrosis and the possibilities to protect against ROS-induced fibrosis.
  • The molecular mechanisms of action of food supplements (like ATP, polyphenols, thiols) focus on antioxidant and anti-inflammatory properties
  • Associated Staff

    Aalt Bast
    Professor

    ​Prof. Dr. Aalt Bast is chairman of the Department of Toxicology at the Maastricht University. He studied chemistry in Amsterdam and did his PhD in Ro more ...

    Guido Haenen
    Professor

    ​Guido Haenen (17/6/1959, Axel, The Netherlands) was registered as a Pharmacist in 1985 (with honors), and he obtained his Ph.D. in Medicinal Chemistr more ...

    Antje Weseler
    Assistant Professor

    ​Dr. Antje R. Weseler graduated in pharmacy at the Heinrich-Heine University in Düsseldorf (Germany) and received her licensure as pharmacist in 1999. more ...

    Gertjan den Hartog
    Assistant Professor

    more ...

    Alie de Boer
    Former Staff

    ​Alie de Boer was born on March 30th 1989 in Heerenveen, the Netherlands. In 2007 she started the bachelors programme Nutrition & Health in Wageningen more ...

    Misha Vrolijk
    PhD Student

    more ...

    Kristien Lemmens
    Former Staff

    ​Kristien Lemmens was born on February the 14th 1986 in Oupeye, Belgium. In September 2004 she started her master study; industrial sciences and techn more ...

    Bregje van de Wier
    Former Staff

    ​Bregje van de Wier studied Medicine at Maastricht University and graduated in 2010. In the last year of her study she did a scientific internship at more ...

    Mireille Sthijns
    PhD Student

    ​Mireille Sthijns was born on February 25th 1991 in Maastricht, the Netherlands. In September 2009 she started the Bachelor Biomedical Sciences, speci more ...

    Marie-José Drittij
    Technician

    ​Marie-José Drittij studied at the ‘Zuidlimburgse Laboratorium School’ in Sittard, The Netherlands. She is specialized in analytical chemistry and ins more ...

    Roger Bartholomé
    Former Staff

    more ...

    Timme van der Lugt
    PhD Student

    more ...

    Gesiele Verissimo
    PhD Student

    more ...

    Ming Zhang
    PhD Student

    Ming Zhang was born on December 23rd 1988 in Henan Province, China. In September 2007, she started the Bachelor study Food Science and Engineering more ...

    Marjolein Drent
    Other

    Prof. Marjolein Drent (1955) studied physical therapy at the Arnhem Academy of Physical Therapy, the Netherlands (NL). She finished her medical study more ...

    Ellen Higgs
    PhD Student

    Ellen Higgs graduated from Keele University in 2014 after studying Biochemistry and Forensic Science. She then enrolled in a Research Masters in Cance more ...

    Philippe Vangrieken
    PhD Student

    Philippe Vangrieken was born on April 29 1992 in Lommel, Belgium. In 2011 he started the Bachelor program Biomedical Sciences at Maastricht University more ...