Department of Pharmacology & Toxicology

Output Department of Toxicology 2013

van Amsterdam J., E. Pennings, T. Brunt, W. van den Brink (2013). "Physical harm due to chronic substance use." Regul Toxicol Pharmacol. 66(1):83-7.

Baranska, A., E. Tigchelaar, A. Smolinska, J. W. Dallinga, E. J. Moonen, J. A. Dekens, C. Wijmenga, A. Zhernakova and F. J. van Schooten (2013). "Profile of volatile organic compounds in exhaled breath changes as a result of gluten-free diet." J Breath Res. 7(3): 037104.

Bast, A. and G. R. Haenen (2013). "Ten misconceptions about antioxidants." Trends Pharmacol Sci. 34(8): 430-436.

Pijls, K.E., de Vries, H., Nikkessen, S., Bast, A., Wodzig, W.K., Koek, GH. (2013) Critical appraisal of 13C breath tests for microsomal liver function: aminopyrine revisited. Liver Int. [Epub ahead of print].

Bast, A., W. Briggs, E. Calabrese, M. Fenech, J. Hanekamp, R. Heaney, G. Rijkers, B. Schwitters (2013). "Scientism, legalism and precaution - Contending with regulating nutrition and health claims in Europe". EFFL (6) 401.

Baumgartner, S., R. P. Mensink, G. den Hartog, A. Bast, O. Bekers, C. Husche, D. Lutjohann and J. Plat (2013). "Oxyphytosterol formation in humans: identification of high vs. low oxidizers." Biochem Pharmacol. 86(1): 19-25.

Bieghs, V., T. Hendrikx, P. J. van Gorp, F. Verheyen, Y. D. Guichot, S. M. Walenbergh, M. L. Jeurissen, M. Gijbels, S. S. Rensen, A. Bast, J. Plat, S. C. Kalhan, G. H. Koek, E. Leitersdorf, M. H. Hofker, D. Lutjohann and R. Shiri-Sverdlov (2013). "The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice." Gastroenterology 144(1): 167-178 e161.

Boesten, D. M., A. Berger, P. de Cock, H. Dong, B. D. Hammock, G. J. den Hartog and A. Bast (2013). "Multi-targeted mechanisms underlying the endothelial protective effects of the diabetic-safe sweetener erythritol." PLoS One 8(6): e65741.

Boesten DM, de Vos-Houben JM, Timmermans L, den Hartog GJ, Bast A, Hageman GJ. (2013). "Accelerated aging during chronic oxidative stress: a role for PARP-1.” Oxid Med Cell Longev. 2013: 680414

van den Borst B., A.M. Schols, C. de Theije, A.W. Boots, S.E. Köhler, G.H. Goossens, H.R. Gosker (2013). "Characterization of the inflammatory and metabolic profile of adipose tissue in a mouse model of chronic hypoxia". J Appl Physiol. 114(11):1619-28.

Brouwers O, de Vos-Houben JM, Niessen PM, Miyata T, van Nieuwenhoven F, Janssen BJ, Hageman G, Stehouwer CD, Schalkwijk CG. (2013) “Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression.” Int J Mol Sci. 14(8):15724-39.

Cheah, N. P., J. L. Pennings, J. P. Vermeulen, F. J. van Schooten and A. Opperhuizen (2013). "In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells." Toxicol In Vitro. 27(3): 1072-1081.

Cremers, J. P., M. Drent, A. Bast, H. Shigemitsu, R. P. Baughman, D. Valeyre, N. J. Sweiss and T. L. Jansen (2013). "Multinational evidence-based World Association of Sarcoidosis and Other Granulomatous Disorders recommendations for the use of methotrexate in sarcoidosis: integrating systematic literature research and expert opinion of sarcoidologists worldwide." Curr Opin Pulm Med 19(5): 545-561.

den Hartog GJ, Qi S, van Tilburg JH, Koek GH, Bast A. “Superoxide anion radicals activate hepatic stellate cells after entry through chloride channels: A new target in liver fibrosis.” Eur J Pharmacol. 2013 Dec 28. [Epub ahead of print]

Ersson, C., P. Moller, L. Forchhammer, S. Loft, A. Azqueta, R. W. Godschalk, F. J. van Schooten, G. D. Jones, J. A. Higgins, M. S. Cooke, V. Mistry, M. Karbaschi, D. H. Phillips, O. Sozeri, M. N. Routledge, K. Nelson-Smith, P. Riso, M. Porrini, G. Matullo, A. Allione, M. Stepnik, M. Ferlinska, J. P. Teixeira, S. Costa, L. A. Corcuera, A. Lopez de Cerain, B. Laffon, V. Valdiglesias, A. R. Collins and L. Moller (2013). "An ECVAG inter-laboratory validation study of the comet assay: inter-laboratory and intra-laboratory variations of DNA strand breaks and FPG-sensitive sites in human mononuclear cells." Mutagenesis 28(3): 279-286.

Etemadi, A., F. Islami, D. H. Phillips, R. Godschalk, A. Golozar, F. Kamangar, A. F. Malekshah, A. Pourshams, S. Elahi, F. Ghojaghi, P. T. Strickland, P. R. Taylor, P. Boffetta, C. C. Abnet, S. M. Dawsey, R. Malekzadeh and F. J. van Schooten (2013). "Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype." Int J Cancer 132(12): 2738-2747.

Gerloff K, Pereira DI, Faria N, Boots AW, Kolling J, Förster I, Albrecht C, Powell JJ, Schins RP. (2013) “Influence of simulated gastrointestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells.” Nanotoxicology. 7(4):353-66

Geybels MS, Verhage BA, Arts IC, van Schooten FJ, Goldbohm RA, van den Brandt PA. (2013). "Dietary flavonoid intake, black tea consumption, and risk of overall and advanced stage prostate cancer." Am J Epidemiol. 177(12): 1388-1398.

Geybels, M.S. , B.A. Verhage, F. J. van Schooten, R. A. Goldbohm and P. A. van den Brandt. (2013) “Advanced prostate cancer risk in relation to toenail selenium levels.” J Natl Cancer Inst. 105(18):1394-401.

Godschalk, R. W., C. Ersson, P. Riso, M. Porrini, S. A. Langie, F. J. van Schooten, A. Azqueta, A. R. Collins, G. D. Jones, R. W. Kwok, D. H. Phillips, O. Sozeri, A. Allione, G. Matullo, L. Moller, L. Forchhammer, S. Loft and P. Moller (2013). "DNA-repair measurements by use of the modified comet assay: an inter-laboratory comparison within the European Comet Assay Validation Group (ECVAG)." Mutat Res 757(1): 60-7.

Van Helden Y., R.W.L. Godschalk, F.J. van Schooten and J. Keijer (2013). “Organ specificity of beta-carotene induced lung gene-expression changes in Bcmo1-/- mice.” Mol Nutr Food Res. 57: 307-319.

Klinkenberg, L. J., P. T. Res, G. R. Haenen, A. Bast, L. J. van Loon, M. P. van Dieijen-Visser and S. J. Meex (2013). "Effect of antioxidant supplementation on exercise-induced cardiac troponin release in cyclists: a randomized trial." PLoS One 8(11): e79280.

Knapen LM, Dittrich ST, de Vries F, Starup-Linde J, Vestergaard P, Henry RM, Stolk LM, Neef C, Bazelier MT. (2013) “Use of biguanides and the risk of colorectal cancer: a register-based cohort study.” Curr Drug Saf. 8(5):349-56.

Langie, S. A., S. Achterfeldt, J. P. Gorniak, K. J. Halley-Hogg, D. Oxley, F. J. van Schooten, R. W. Godschalk, J. A. McKay and J. C. Mathers (2013). "Maternal folate depletion and high-fat feeding from weaning affects DNA methylation and DNA repair in brain of adult offspring." FASEB J. 27(8): 3323-3334.

Linschooten, J. O., N. Verhofstad, K. Gutzkow, A. K. Olsen, C. Yauk, Y. Oligschlager, G. Brunborg, F. J. van Schooten and R. W. Godschalk (2013). "Paternal lifestyle as a potential source of germline mutations transmitted to offspring." FASEB J. 27(7): 2873-2879.

Merlo, D. F., S. Agramunt, L. Anna, H. Besselink, M. Botsivali, N. J. Brady, M. Ceppi, L. Chatzi, B. Chen, I. Decordier, P. B. Farmer, S. Fleming, V. Fontana, A. Forsti, E. Fthenou, F. Gallo, P. Georgiadis, H. Gmuender, R. W. Godschalk, B. Granum, L. J. Hardie, K. Hemminki, K. Hochstenbach, L. E. Knudsen, M. Kogevinas, K. Kovacs, S. A. Kyrtopoulos, M. Lovik, J. K. Nielsen, U. C. Nygaard, M. Pedersen, P. Rydberg, B. Schoket, D. Segerback, R. Singh, J. Sunyer, M. Tornqvist, H. van Loveren, F. J. van Schooten, K. Vande Loock, H. von Stedingk, J. Wright, J. C. Kleinjans, M. Kirsch-Volders and J. H. van Delft (2013). "Micronuclei in Cord Blood Lymphocytes and Associations with Biomarkers of Exposure to Carcinogens and Hormonally Active Factors, Gene Polymorphisms, and Gene Expression: The NewGeneris Cohort." Environ Health Perspect. 2013 [Epub ahead of print].

Nergiz-Ünal, R., MJE Kuijpers, SM de Witt, S Heeneman, MAH Feijge, SC Garcia Caraballo, EAL Biessen, GRMM Haenen, JMEM Cosemans, JWM Heemskerk (2013) “Atheroprotective effect of dietary walnut intake in ApoE-deficient mice: Involvement of lipids and coagulation factors.” Thrombosis research. 131(5): 411-7.

Pedersen, M., B. Schoket, R. W. Godschalk, J. Wright, H. von Stedingk, M. Tornqvist, J. Sunyer, J. K. Nielsen, D. F. Merlo, M. A. Mendez, H. M. Meltzer, V. Lukacs, A. Landstrom, S. A. Kyrtopoulos, K. Kovacs, L. E. Knudsen, M. Haugen, L. J. Hardie, K. B. Gutzkow, S. Fleming, E. Fthenou, P. B. Farmer, A. Espinosa, L. Chatzi, G. Brunborg, N. J. Brady, M. Botsivali, K. Arab, L. Anna, J. Alexander, S. Agramunt, J. C. Kleinjans, D. Segerback and M. Kogevinas (2013). "Bulky DNA adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)." Environ Health Perspect. 121(10): 1200-1206.

Peluso, M., A. Munnia, M. Ceppi, R. W. Giese, D. Catelan, F. Rusconi, R. W. Godschalk and A. Biggeri (2013). "Malondialdehyde-deoxyguanosine and bulky DNA adducts in schoolchildren resident in the proximity of the Sarroch industrial estate on Sardinia Island, Italy." Mutagenesis 28(3): 315-321.

Peluso, M., P. Srivatanakul, A. Jedpiyawongse, S. Sangrajrang, A. Munnia, S. Piro, M. Ceppi, P. Boffetta, R. W. Godschalk and F. J. van Schooten (2013). "Aromatic DNA adducts and number of lung cancer risk alleles in Map-Ta-Phut Industrial Estate workers and nearby residents." Mutagenesis 28(1): 57-63.

Peluso, M. E., A. Munnia, P. Srivatanakul, A. Jedpiyawongse, S. Sangrajrang, M. Ceppi, R. W. Godschalk, F. J. van Schooten and P. Boffetta (2013). "DNA adducts and combinations of multiple lung cancer at-risk alleles in environmentally exposed and smoking subjects." Environ Mol Mutagen 54(6): 375-383.

Pouwels S, Bazelier MT, de Boer A, Weber WE, Neef CK, Cooper C, de Vries F. (2013) “Five-year fracture risk estimation in patients with Parkinson's disease.” Bone. 56(2):266-70.

Pouwels S, Bazelier MT, de Boer A, Weber WE, Neef C, Cooper C, de Vries F.(2013) “Risk of fracture in patients with Parkinson's disease.” Osteoporos Int. 24(8):2283-90.

Quaak, M., F. J. van Schooten and C. P. van Schayck (2013). "[Pharmacogenetics in the treatment of tobacco addiction]." Tijdschr Psychiatr 55(11): 891-898.

Res, P. T., N. M. Cermak, R. Stinkens, T. J. Tollakson, G. R. Haenen, A. Bast and L. J. Van Loon (2013). "Astaxanthin supplementation does not augment fat use or improve endurance performance." Med Sci Sports Exerc 45(6): 1158-1165.

Robroeks, C. M., J. J. van Berkel, Q. Jobsis, F. J. van Schooten, J. W. Dallinga, E. F. Wouters and E. Dompeling (2013). "Exhaled volatile organic compounds predict exacerbations of childhood asthma in a 1-year prospective study." Eur Respir J 42(1): 98-106.

Ruijters, E. J., A. R. Weseler, C. Kicken, G. R. Haenen and A. Bast (2013). "The flavanol (-)-epicatechin and its metabolites protect against oxidative stress in primary endothelial cells via a direct antioxidant effect." Eur J Pharmacol. 715(1-3): 147-153.

Scheepers-Hoeks AM, Grouls RJ, Neef C, Ackerman EW, Korsten EH. (2013) “Physicians' responses to clinical decision support on an intensive care unit--comparison of four different alerting methods.” Artif Intell Med. 59(1):33-8.

Schults, M. A., R. K. Chiu, P. W. Nagle, L. C. Wilms, J. C. Kleinjans, F. J. van Schooten and R. W. Godschalk (2013). "Genetic polymorphisms in catalase and CYP1B1 determine DNA adduct formation by benzo(a)pyrene ex vivo." Mutagenesis. 28(2): 181-185.

Schults, M. A., Y. Oligschlaeger, R. W. Godschalk, F. J. Van Schooten and R. K. Chiu (2013). "Loss of VHL in RCC Reduces Repair and Alters Cellular Response to Benzo[a]pyrene." Front Oncol. 3: 270.

van de Kant, K. D., J. J. van Berkel, Q. Jobsis, V. Lima Passos, E. M. Klaassen, L. van der Sande, O. C. van Schayck, J. C. de Jongste, F. J. van Schooten, E. Derks, E. Dompeling and J. W. Dallinga (2013). "Exhaled breath profiling in diagnosing wheezy preschool children." Eur Respir J. 41(1): 183-188.

van de Wier, B., J. M. Balk, G. R. Haenen, D. Giamouridis, J. A. Bakker, B. C. Bast, G. J. den Hartog, G. H. Koek and A. Bast (2013). "Elevated citrate levels in non-alcoholic fatty liver disease: the potential of citrate to promote radical production." FEBS Lett. 587(15): 2461-2466.

van Kesteren, P. C., P. E. Zwart, M. M. Schaap, T. E. Pronk, M. H. van Herwijnen, J. C. Kleinjans, B. G. Bokkers, R. W. Godschalk, M. J. Zeilmaker, H. van Steeg and M. Luijten (2013). "Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons. Arch Toxicol. 87(3):505-15.

van Leeuwen RW, Brundel DH, Neef C, van Gelder T, Mathijssen RH, Burger DM, Jansman FG. (2013) “Prevalence of potential drug-drug interactions in cancer patients treated with oral anticancer drugs.” Br J Cancer. 108(5):1071-8.

Vanhees, K., F. J. van Schooten, S. B. van Waalwijk van Doorn-Khosrovani, S. van Helden, A. Munnia, M. Peluso, J. J. Briede, G. R. Haenen and R. W. Godschalk (2013). "Intrauterine exposure to flavonoids modifies antioxidant status at adulthood and decreases oxidative stress-induced DNA damage." Free Radic Biol Med. 57: 154-161.

Verdam, F. J., J. W. Dallinga, A. Driessen, C. de Jonge, E. J. Moonen, J. B. van Berkel, J. Luijk, N. D. Bouvy, W. A. Buurman, S. S. Rensen, J. W. Greve and F. J. van Schooten (2013). "Non-alcoholic steatohepatitis: a non-invasive diagnosis by analysis of exhaled breath." J Hepatol. 58(3): 543-548.

Wijnen, P. A., J. A. Verschakelen, A. Bast, O. Bekers and M. Drent (2013) "Diffuse alveolar hemorrhage in coumarin users: a fibrosing interstitial pneumonia trigger?" Lung. 191(1): 53-59.

Wong DR, Pierik M, Seinen ML, van Bodegraven AA, Gilissen LP, Bus P, Bakker JA, Masclee AA, Neef C, Engels LG, Hooymans PM. (2013) “The pharmacokinetic effect of adalimumab on thiopurine metabolism in Crohn's disease patients.” J Crohns Colitis. [Epub ahead of print]

Yelisyeyeva, O. P., K. O. Semen, G. V. Ostrovska, D. V. Kaminskyy, T. V. Sirota, N. Zarkovic, D. Mazur, O. D. Lutsyk, K. Rybalchenko and A. Bast (2014). "The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress." Food Chem. 147: 152-159.

Yu Y, Teerenstra S, Vanmolkot F, Neef C, Burger D, Maliepaard M. (2013) “Interchangeability of gabapentin generic formulations in the Netherlands: a comparative bioavailability study.” Clin Pharmacol Ther. 94(4):519-24.