We investigate how cardiac regeneration can be achieved after a myocardial infarction, particularly through modulating Wnt signaling pathways. We investigate how interventions in Wnt signaling can stimulate cardiomyocyte proliferation, aiming to repair myocardial infarction-induced damage by promoting heart tissue regeneration over scar formation. Additionally, we explore the complex interactions between Wnt signaling and other pathways in cardiac remodeling and heart failure, striving to develop therapeutic strategies that enhance the heart's intrinsic regenerative capabilities.

Lead scientist: Matthijs Blankesteijn