The field of toxicology has witnessed significant advancements in analytical techniques, driven by the need to better understand and quantify inflammation in biological systems and compounds that may inhibit inflammation or oxidative stress. Therefore, we develop methodologies to measure biomarkers for inflammatory parameters, such as cytokines, leukotrienes and oxidative stress markers. Recent developments in technologies like liquid chromatography-mass spectrometry (LC-MS) have revolutionized the ability to detect and quantify these biomarkers at trace levels in complex biological matrices. These techniques can also be used for the analysis of bioactive compounds that modulate inflammation. These tools not only enhance our understanding of toxicological mechanisms but also support regulatory frameworks for health and safety.

Lead scientist

Gertjan den Hartog