Department of Pharmacology & Toxicology

Output 2014

Publications

Bast A, Hanekamp JC "You can't always get what you want" - Linearity as the golden ratio of Toxicology, 2014 Dose-Response. In press.

van Berlo D, Wilhelmi V, Boots AW, Hullmann M, Kuhlbusch TA, Bast A, Schins RP, Albrecht C. Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung. Arch Toxicol. 2014 Mar 25. In press.

Boer de A, Vos E, Bast A. Implementation of the nutrition and health claim regulation - The case of antioxidants. Regul Toxicol Pharmacol. 2014 Feb 10;68(3):475-487.

Daniëlle M.P.H.J. Boesten, Atlanta G.I.M. Elie, Marie-José Drittij-Reijnders,Gertjan J.M. den Hartog, Aalt Bast Carboxymethyllysine on oxidative stress and theglutathione system in beta cells Toxicology Reports 1 (2014) 973–980

Boots AW, Smolinska A, van Berkel JJ, Fijten RR, Stobberingh EE, Boumans ML, Moonen EJ, Wouters EF, Dallinga JW, Van Schooten FJ. Identification of microorganisms based on headspace analysis of volatile organic compounds by gas chromatography-mass spectrometry. J Breath Res. 2014 Apr 16;8(2):027106.

Dallinga JW, Smolinska A, van Schooten FJ Analysis of volatile organic compounds in exhaled breath by gas chromatography-mass spectrometry combined with chemometric analysis. Methods Mol Biol. 2014;1198:251-63.

Deckers IA, van den Brandt PA, van Engeland M, van Schooten FJ, Godschalk RW, Keszei AP, Schouten LJ.

Polymorphisms in genes of the renin-angiotensin-aldosterone system and renal cell cancer risk: Interplay with hypertension and intakes of sodium, potassium and fluid. Int J Cancer. 2014 Jun 30. In press.

Driessen JH, van Onzenoort HA, Henry RM, Lalmohamed A, van den Bergh JP, Neef C, Leufkens HG, de Vries F. Use of dipeptidyl peptidase-4 inhibitors for type 2 diabetes mellitus and risk of fracture. Bone. 2014 Aug 2. pii: S8756-3282(14)00293-2. doi: 10.1016/j.bone.2014.07.030. [Epub ahead of print]

Duvivier WF, van Beek TA, Pennings EJM, Nielen MWF. Rapid analysis of ∆-9-tetrahydrocannabinol in hair using direct analysis in real time ambient ionization orbitrap mass spectrometry. Rapid Commun Mass Spectrom 2014, 28, 682-690.

van Ganzewinkel C, Derijks L, Anand KJ, van Lingen RA, Neef C, Kramer BW, Andriessen P. Multiple intravenous doses of paracetamol result in a predictable pharmacokinetic profile in very preterm infants.Acta Paediatr. 2014 Jun;103(6):612-7

Geybels MS, van den Brandt PA, Schouten LJ, van Schooten FJ, van Breda SG, Rayman MP, Green FR, Verhage BA. Selenoprotein Gene Variants, Toenail Selenium Levels, and Risk of Advanced Prostate Cancer. J Natl Cancer Inst. 2014 Feb 22. In press.

Geybels MS, van den Brandt PA, van Schooten FJ, Verhage BA. Oxidative stress-related genetic variants, pro- and antioxidant intake and status, and advanced prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 2014 Oct 14.

Gielen M, Hageman G, Pachen D, Derom C, Vlietinck R, Zeegers MP. Placental telomere length decreases with gestational age and is influenced by parity: A study of third trimester live-born twins. Placenta. 2014 Oct;35(10):791-6. doi: 10.1016/j.placenta.2014.05.010. Epub 2014 Jun 6.

Godschalk RW, Ersson C, Stępnik M, Ferliłska M, Palus J, Teixeira JP, Costa S, Jones GD, Higgins JA, Kain J, Möller L, Forchhammer L, Loft S, Lorenzo Y, Collins AR, van Schooten FJ, Laffon B, Valdiglesias V, Cooke M, Mistry V, Karbaschi M, Phillips DH, Sozeri O, Routledge MN, Nelson-Smith K, Riso P, Porrini M, López de Cerain A, Azqueta A, Matullo G, Allione A, Møller P. Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories. Mutagenesis. 2014 Jul;29(4):241-9.

Haenen GR, Bast A. Glutathione revisited: a better scavenger than previously thought. Front Pharmacol. 2014 Nov 27;5:260.

Haeseker M, Havenith T, Stolk L, Neef C, Bruggeman C, Verbon A. Is the standard dose of amoxicillin-clavulanic acid sufficient? BMC Pharmacol Toxicol. 2014 Jul 21;15(1):38.

Haeseker MB, Croes S, Neef C, Bruggeman CA, Stolk LM, Verbon A. Vancomycin dosing in neutropenic patients. PLoS One. 2014 Nov 12;9(11):e112008.

Hanekamp JC, Bast A. Antibiotics exposure and health risks: Chloramphenicol. Environ Toxicol Pharmacol. 2014 Dec 4;39(1):213-220. [Epub ahead of print] Review.

den Hartog GJ, Qi S, van Tilburg JH, Koek GH, Bast A. Superoxide anion radicals activate hepatic stellate cells after entry through chloride channels: A new target in liver fibrosis. Eur J Pharmacol. 2014 Feb 5;724:140-4.

Hazewindus M, Haenen GR, Weseler AR, Bast A. Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup. PLoS One. 2014 Dec 31;9(12):e114387.

Hogervorst JG, Godschalk RW, van den Brandt PA, Weijenberg MP, Verhage BA, Jonkers L, Goessens J, Simons CC, Vermeesch JR, van Schooten FJ, Schouten LJ. DNA from nails for genetic analyses in large-scale epidemiologic studies. Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2703-12.

Hazewindus M, Haenen GR, Weseler AR, Bast A. Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup. PLoS One. 2014 Dec 31;9(12):e114387.

Kelly ER, Plat J, Haenen GR, Kijlstra A, Berendschot TT. The effect of modified eggs and an egg-yolk based beverage on serum lutein and zeaxanthin concentrations and macular pigment optical density: results from a randomized trial. PLoS One. 2014 Mar 27;9(3):e92659. In press.

Kerkhofs T, Derijks L, Ettaieb M, den Hartigh J, Neef C, Gelderblom H, Guchelaar HJ, Haak H. Development of a Pharmacokinetic Model of Mitotane: Towards Personalized Dosing in Adrenocortical Carcinoma. Ther Drug Monit. 2014 May 30. In press.

Klaassen EM, van de Kant KD, Jöbsis Q, Penders J, van Schooten FJ, Quaak M, den Hartog GJ, Koppelman GH, van Schayck CP, van Eys G, Dompeling E. Integrative genomic analysis identifies a role for intercellular adhesion molecule 1 in childhood asthma. Pediatr Allergy Immunol. 2014 Mar;25(2):166-72.

Langie SA, Kowalczyk P, Tomaszewski B, Vasilaki A, Maas LM, Moonen EJ, Palagani A, Godschalk RW, Tudek B, van Schooten FJ, Berghe WV, Zabielski R, Mathers JC. Redox and epigenetic regulation of the APE1 gene in the hippocampus of piglets: The effect of early life exposures. DNA Repair (Amst). 2014 Jun;18:52-62.

Lemmens KJ, van de Wier B, Vaes N, Ghosh M, van Zandvoort MA, van der Vijgh WJ, Bast A, Haenen GR. The flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside is able to protect endothelial cells by a direct antioxidant effect. Toxicol In Vitro. 2014 Jun;28(4):538-43

Lemmens KJ, van de Wier B, Koek GH, Köhler E, Drittij MJ, van der Vijgh WJ, Bast A, Haenen GR. The flavonoid monoHER promotes the adaption to oxidative stress during the onset of NAFLD. Biochem Biophys Res Commun. 2015 Jan 2;456(1):179-82

Lemmens KJ, Vrolijk MF, Bouwman FG, van der Vijgh WJ, Bast A, Haenen GR. The Minor Structural Difference between the Antioxidants Quercetin and 4'O-Methylquercetin Has a Major Impact on Their Selective Thiol Toxicity. Int J Mol Sci. 2014 Apr 30;15(5):7475-84.

van Maarseveen E, van Buul-Gast MC, Abdoellakhan R, Gelinck L, Neef C, Touw D. Once-daily dosed gentamicin is more nephrotoxic than once-daily dosed tobramycin in clinically infected patients. J Antimicrob Chemother. 2014 May 28.

Marsch E, Theelen TL, Demandt JA, Jeurissen M, van Gink M, Verjans R, Janssen A, Cleutjens JP, Meex SJ, Donners MM, Haenen GR, Schalkwijk CG, Dubois LJ, Lambin P, Mallat Z, Gijbels MJ, Heemskerk JW, Fisher EA, Biessen EA, Janssen BJ, Daemen MJ, Sluimer JC. Reversal of Hypoxia in Murine Atherosclerosis Prevents Necrotic Core Expansion by Enhancing Efferocytosis. Arterioscler Thromb Vasc Biol. 2014 Sep 25.

Merlo DF, Agramunt S, Anna L, Besselink H, Botsivali M, Brady NJ, Ceppi M, Chatzi L, Chen B, Decordier I, Farmer PB, Fleming S, Fontana V, Försti A, Fthenou E, Gallo F, Georgiadis P, Gmuender H, Godschalk RW, Granum B, Hardie LJ, Hemminki K, Hochstenbach K, Knudsen LE, Kogevinas M, Kovács K, Kyrtopoulos SA, Løvik M, Nielsen JK, Nygaard UC, Pedersen M, Rydberg P, Schoket B, Segerbäck D, Singh R, Sunyer J, Törnqvist M, van Loveren H, van Schooten FJ, Vande Loock K, von Stedingk H, Wright J, Kleinjans JC, Kirsch-Volders M, van Delft JH. Micronuclei in Cord Blood Lymphocytes and Associations with Biomarkers of Exposure to Carcinogens and Hormonally Active Factors, Gene Polymorphisms, and Gene Expression: The NewGeneris Cohort. Environ Health Perspect. 2014 Feb;122(2):193-200

Meyer N, Dallinga JW, Nuss SJ, Moonen EJC, Van Berkel JJBN, Akdis C, Van Schooten FJ, Menz G. Defining adult asthma endotypes by clinical features and patterdns of volatile organic compounds in exhaled air. Respiratory Research 2014;15:136

Milenkovic D, Vanden Berghe W, Boby C, Leroux C, Declerck K, Szarc Vel Szic K, Heyninck K, Laukens K, Bizet M, Defrance M, Dedeurwaerder S, Calonne E, Fuks F, Haegeman G, Haenen GR, Bast A, Weseler AR.

Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State. PLoS One. 2014 Apr 24;9(4):e95527.

Pennings EJM. Forensisch toxicologisch onderzoek. Bijblijven 2014;2:33-40

Pijls KE, de Vries H, Nikkessen S, Bast A, Wodzig WK, Koek GH. Critical appraisal of (13) C breath tests for microsomal liver function: aminopyrine revisited. Liver Int. 2014 Apr;34(4):487-94.

Quaak M, van Schooten FJ, van Schayck CP. Pharmacogenetics of smoking: how far to the clinic? Pharmacogenomics. 2014 Apr;15(6):723-6.

Robijns K, Boone NW, Kuypers AW, Jansen RT, Neef C, Touw DJ. A multi laboratory commutability evaluation of proficiency testing material for carbamazepine and valproic acid: a study within the framework of the Dutch Calibration 2000 project. The Drug Monit. 2014 Dec 18. [Epub ahead of print]

Ruijters EJ, Haenen GR, Weseler AR, Bast A. The anti-inflammatory efficacy of dexamethasone is protected by (-)-epicatechin. PharmaNutrition 2(2014) 47-52

Ruijters EJ, Haenen GR, Weseler AR, Bast A. The cocoa flavanol (-)-epicatechin protects the cortisol response. Pharmacol Res 2014 Jan;79:28-33

Schults MA, Sanen K, Godschalk RW, Theys J, van Schooten FJ, Chiu RK. Hypoxia diminishes the detoxification of the environmental mutagen benzo[a]pyrene. Mutagenesis. 2014 Nov;29(6):481-7.

Smolinska A, Hauschild Ach, Fijtten RRR, Dallinga JW, Baumbach J and Van Schooten FJ. Current breathomics—a review on data pre-processing techniques and machine learning in metabolomics breath analysis. J Breath Res. 2014 Jun;8(2):027105.

Smolinska A, Klaassen EM, Dallinga JW, van de Kant KD, Jobsis Q, Moonen EJ, van Schayck OC, Dompeling E, van Schooten FJ. Profiling of volatile organic compounds in exhaled breath as a strategy to find early predictive signatures of asthma in children. PLoS One. 2014 Apr 21;9(4):e95668.

Stifft F, Vanmolkot F, Scheffers I, van Bortel L, Neef C, Christiaans M. Rectal and Sublingual Administration of Tacrolimus: a Single Dose Pharmacokinetic Study in Healthy Volunteers. Br J Clin Pharmacol. 2014 May 9.

Sthijns MM, Randall MJ, Bast A, Haenen GR. Adaptation to acrolein through upregulating the protection by glutathione in human bronchial epithelial cells: The materialization of the hormesis concept. Biochem Biophys Res Commun. 2014 Apr 18;446(4):1029-34.

Vafeiadi M, Agramunt S, Pedersen M, Besselink H, Chatzi L, Fthenou E, Fleming S, Hardie LJ, Wright J, Knudsen LE, Nielsen JK, Sunyer J, Carreras R, Brunborg G, Gutzkow KB, Nygaard UC, Løvik M, Kyrtopoulos SA, Segerbäck D, Merlo DF, Kleinjans JC, Vrijheid M, Kogevinas M; NewGeneris Consortium. In utero exposure to compounds with dioxin-like activity and birth outcomes. Epidemiology. 2014 Mar;25(2):215-24.

Vanhees K, Vonhögen IG, van Schooten FJ, Godschalk RW. You are what you eat, and so are your children: the impact of micronutrients on the epigenetic programming of offspring. Cell Mol Life Sci. 2014 Jan;71(2):271-85

de Vries PS, Gielen M, Rizopoulos D, Rump P, Godschalk R, Hornstra G, Zeegers MP. Association between polyunsaturated fatty acid concentrations in maternal plasma phospholipids during pregnancy and offspring adiposity at age 7: The MEFAB cohort. Prostaglandins Leukot Essent Fatty Acids. 2014 Apr 25. In press.

van Maarseveen EM, Bouma A, Touw DJ, Neef C, van Zanten AR. Design and prospective validation of a dosing instrument for continuous infusion of vancomycin: a within-population approach. Eur J Clin Pharmacol. 2014 Aug 30.

Vrolijk MF, Haenen GR, Opperhuizen A, Jansen EH, Schiffers PM, Bast A. The supplement-drug interaction of quercetin with tamsulosin on vasorelaxation. Eur J Pharmacol. 2014 Nov 15;746C:132-137.

Wier van de B, Koek G, Bast A, Haenen GR The potential of flavonoids in the treatment of non-alcoholic fatty liver disease. Critical Reviews in Food Science and Nutrition, In press

Wong DR, Pierik M, Seinen ML, van Bodegraven AA, Gilissen LP, Bus P, Bakker JA, Masclee AA, Neef C, Engels LG, Hooymans PM. The pharmacokinetic effect of adalimumab on thiopurine metabolism in Crohn's disease patients. J Crohns Colitis. 2014 Feb 1;8(2):120-8

Yelisyeyeva OP, Semen KO, Ostrovska GV, Kaminskyy DV, Sirota TV, Zarkovic N, Mazur D, Lutsyk OD, Rybalchenko K, Bast A The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress. Food Chem 2014 Mar 15;147:152-9.

Zanoni TB, Tiago M, Faião-Flores F, Barros SB, Bast A, Hageman G, Oliveira DP, Maria-Engler SS Basic Red 51, a permitted semi-permanent hair dye, is cytotoxic to human skin cells: Studies in monolayer and 3(D) skin model using human keratinocytes (HaCaT) Toxicol Lett. 2014 Jun 5;227(2):139-49.

Bookchapters

Bast A, Haenen GRMM, Nutritional Antioxidants: It is time to categorise In: Antioxidants in sport nutrition, Ch.2: 17-38

Van Schooten FJ, Boots AW, Smolinska A, Dallinga JW. Volatile organic compounds as exhaled biomarkers of inflammation and oxidative stress in respiratory diseases. In: Oxidative stress in applied basic research and clinical practice: Studies on respiratory disorders, Ch.4, pp. 67-84. NK Ganguly, SK Jindal, S Biswal, PJ Barnes and R Pawankar (editors), Humana Press, Springer Science Business Media, New York, 2014.

Voedingssupplementen in: Diagnose en therapie 2015-2016, II Bijzondere vormen van behandeling, p 981-1003 ISBN 978-90-368-0609-1 Springer Media, Bohn Stafleu Van Loghum

PhD-Theses

Mohamed Moalin
Quercetin and its methylated metabolites: The chemical basis of activity.
​Date thesis defense: 11 June 2014
​Supervisor: Prof Dr Bast
​Co-supervisors: Dr G Haenen en Dr G van Strydonck

Matthew J Randall
Covalent protein modification by acrolein: toxicity and adaptation.
​Date thesis defense: 25 June 2014
​Supervisor: Prof Dr A Bast
​Co-supervisors: Dr G Haenen en Prof Dr A van der Vliet

D Boesten
Polyols and polyphenols against glucotoxicity
​Date thesis defense: 1 December 2014
​Supervisor: A Bast
​Co-supervisor: GJ den Hartog

E Ruijters
Health benefits of (−)-epicatechin and other flavonoids.
​Date thesis defense: 9 December 2014
​Supervisor: A Bast
​Co-supervisors: G Haenen en A Weseler