Department of Pharmacology & Toxicology

WI Publications 2012

Adenosine 5'-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans. Arts IC, Coolen EJ, Bours MJ, Huyghebaert N, Stuart MA, Bast A, Dagnelie PC. J Int Soc Sports Nutr. 2012 Apr 17;9(1):16. doi: 10.1186/1550-2783-9-16.

Are smokers interested in genetic testing for smoking addiction? A socio-cognitive approach. Smerecnik C, Quaak M, van Schayck CP, van Schooten FJ, de Vries H. Psychol Health. 2011 Aug;26(8):1099-112. doi: 10.1080/08870446.2010.541909. Epub 2011 Jun 28.

Aromatic DNA adducts and number of lung cancer risk alleles in Map-Ta-Phut Industrial Estate workers and nearby residents. Peluso M, Srivatanakul P, Jedpiyawongse A, Sangrajrang S, Munnia A, Piro S, Ceppi M, Boffetta P, Godschalk RW, van Schooten FJ. Mutagenesis. 2013 Jan;28(1):57-63. doi: 10.1093/mutage/ges053. Epub 2012 Sep 17.

Astaxanthin Supplementation Does Not Augment Fat Use or Improve Endurance Performance. Res PT, Cermak NM, Stinkens R, Tollakson TJ, Haenen GR, Bast A, van Loon LJ. Med Sci Sports Exerc. 2012 Dec 27. [Epub ahead of print]

Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: Toxicokinetics is essential for in vivo-in vitro comparisons. van Kesteren PC, Zwart PE, Schaap MM, Pronk TE, van Herwijnen MH, Kleinjans JC, Bokkers BG, Godschalk RW, Zeilmaker MJ, van Steeg H, Luijten M. Arch Toxicol. 2012 Oct 2. [Epub ahead of print]

Breath analysis as a potential diagnostic tool for tuberculosis. Kolk AH, van Berkel JJ, Claassens MM, Walters E, Kuijper S, Dallinga JW, van Schooten FJ. Int J Tuberc Lung Dis. 2012 Jun;16(6):777-82. doi: 10.5588/ijtld.11.0576. Epub 2012 Apr 9.

Cat litter is a possible trigger for sarcoidosis. Drent M, Wijnen PA, Boots AW, Bast A. Eur Respir J. 2012 Jan;39(1):221-2. doi: 10.1183/09031936.00074411. No abstract available.

Cigarette smoke-induced transgenerational alterations in genome stability in cord blood of human F1 offspring. Laubenthal J, Zlobinskaya O, Poterlowicz K, Baumgartner A, Gdula MR, Fthenou E, Keramarou M, Hepworth SJ, Kleinjans JC, van Schooten FJ, Brunborg G, Godschalk RW, Schmid TE, Anderson D. FASEB J. 2012 Oct;26(10):3946-56. doi: 10.1096/fj.11-201194. Epub 2012 Jun 22.

Competition between ascorbate and glutathione for the oxidized form of methylated quercetin metabolites and analogues: tamarixetin, 4'O-methylquercetin, has the lowest thiol reactivity. Moalin M, van Strijdonck GP, Bast A, Haenen GR. J Agric Food Chem. 2012 Sep 12;60(36):9292-7. doi: 10.1021/jf302068v. Epub 2012 Aug 27.

Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity. Schults MA, Nagle PW, Rensen SS, Godschalk RW, Munnia A, Peluso M, Claessen SM, Greve JW, Driessen A, Verdam FJ, Buurman WA, van Schooten FJ, Chiu RK. Mutat Res. 2012 Aug 1;736(1-2):75-81. doi: 10.1016/j.mrfmmm.2011.11.001. Epub 2011 Nov 7.

Diffuse Alveolar Hemorrhage in Coumarin Users: A Fibrosing Interstitial Pneumonia Trigger? Wijnen PA, Verschakelen JA, Bast A, Bekers O, Drent M. Lung. 2012 Nov 13. [Epub ahead of print]

Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability. Schults MA, Timmermans L, Godschalk RW, Theys J, Wouters BG, van Schooten FJ, Chiu RK. J Biol Chem. 2010 May 7;285(19):14558-64. doi: 10.1074/jbc.M109.076323. Epub 2010 Mar 12.

Distinctive toxicity of TiO2 rutile/anatase mixed phase nanoparticles on Caco-2 cells. Gerloff K, Fenoglio I, Carella E, Kolling J, Albrecht C, Boots AW, Förster I, Schins RP. Chem Res Toxicol. 2012 Mar 19;25(3):646-55. doi: 10.1021/tx200334k. Epub 2012 Feb 10.

DNA adducts in skin biopsies and 1-hydroxypyrene in urine of psoriasis patients and healthy volunteers following treatment with coal tar. Roelofzen JH, van der Valk PG, Godschalk R, Dettbarn G, Seidel A, Golsteijn L, Anzion R, Aben KK, van Schooten FJ, Kiemeney LA, Scheepers PT. Toxicol Lett. 2012 Aug 13;213(1):39-44. doi: 10.1016/j.toxlet.2011.06.030. Epub 2011 Jul 23.

Effectiveness of testing for genetic susceptibility to smoking-related diseases on smoking cessation outcomes: a systematic review and meta-analysis. Smerecnik C, Grispen JE, Quaak M. Tob Control. 2012 May;21(3):347-54. doi: 10.1136/tc.2011.042739. Epub 2011 Sep 26. Review.

Efficacy, nephrotoxicity and ototoxicity of aminoglycosides, mathematically modelled for modelling-supported therapeutic drug monitoring. Croes S, Koop AH, van Gils SA, Neef C. Eur J Pharm Sci. 2012 Jan 23;45(1-2):90-100. doi: 10.1016/j.ejps.2011.10.022. Epub 2011 Nov 10.

Exhaled breath profiling in diagnosing wheezy preschool children van de Kant KD, van Berkel JJ, Jöbsis Q, Lima Passos V, Klaassen EM, van der Sande L, van Schayck OC, de Jongste JC, van Schooten FJ, Derks E, Dompeling E, Dallinga JW. Eur Respir J. 2013 Jan;41(1):183-8. doi: 10.1183/09031936.00122411.

Exposure to Polycyclic Aromatic Hydrocarbons Among Never Smokers in Golestan Province, Iran, an Area of High Incidence of Esophageal Cancer - a Cross-Sectional Study with Repeated Measurement of Urinary 1-OHPG in Two Seasons. Islami F, Boffetta P, van Schooten FJ, Strickland P, Phillips DH, Pourshams A, Fazel-Tabar Malekshah A, Godschalk R, Jafari E, Etemadi A, Abubaker S, Kamangar F, Straif K, Møller H, Schüz J, Malekzadeh R. Front Oncol. 2012;2:14. doi: 10.3389/fonc.2012.00014. Epub 2012 Feb 17.

Fusion of metabolomics and proteomics data for biomarkers discovery: case study on the experimental autoimmune encephalomyelitis. Blanchet L, Smolinska A, Attali A, Stoop MP, Ampt KA, van Aken H, Suidgeest E, Tuinstra T, Wijmenga SS, Luider T, Buydens LM. BMC Bioinformatics. 2011 Jun 22;12:254. doi: 10.1186/1471-2105-12-254.

Genetic variants in the serotonin transporter influence the efficacy of bupropion and nortriptyline in smoking cessation. Knowledge, attitudes and preferences regarding genetic testing for smoking cessation. A cross-sectional survey among Dutch smokers. Quaak M, Smerecnik C, van Schooten FJ, de Vries H, van Schayck CP. BMJ Open. 2012 Jan 5;2:e000321. doi: 10.1136/bmjopen-2011-000321. Print 2012.

Genetic variants in the serotonin transporter influence the efficacy of bupropion and nortriptyline in smoking cessation. Quaak M, van Schayck CP, Postma DS, Wagena EJ, van Schooten FJ. Addiction. 2012 Jan;107(1):178-87. doi: 10.1111/j.1360-0443.2011.03534.x. Epub 2011 Sep 21.

Identification of 3,N(4)-etheno-5-methyl-2'-deoxycytidine in human DNA: a new modified nucleoside which may perturb genome methylation. Nair J, Godschalk RW, Nair U, Owen RW, Hull WE, Bartsch H. Chem Res Toxicol. 2012 Jan 13;25(1):162-9. doi: 10.1021/tx200392a. Epub 2012 Jan 3.

Influence of erroneous patient records on population pharmacokinetic modeling and individual bayesian estimation. van der Meer AF, Touw DJ, Marcus MA, Neef C, Proost JH. Ther Drug Monit. 2012 Oct;34(5):526-34. doi: 10.1097/FTD.0b013e3182616937.

Influence of simulated gastrointestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells. Gerloff K, Pereira DI, Faria N, Boots AW, Kolling J, Förster I, Albrecht C, Powell JJ, Schins RP. Nanotoxicology. 2012 Mar 20. [Epub ahead of print]

Inter-laboratory variation in DNA damage using a standard comet assay protocol. Forchhammer L, Ersson C, Loft S, Möller L, Godschalk RW, van Schooten FJ, Jones GD, Higgins JA, Cooke M, Mistry V, Karbaschi M, Collins AR, Azqueta A, Phillips DH, Sozeri O, Routledge MN, Nelson-Smith K, Riso P, Porrini M, Matullo G, Allione A, Steepnik M, Komorowska M, Teixeira JP, Costa S, Corcuera LA, López de Cerain A, Laffon B, Valdiglesias V, Møller P. Mutagenesis. 2012 Nov;27(6):665-72. doi: 10.1093/mutage/ges032. Epub 2012 Jul 27.

Interpretation and visualization of non-linear data fusion in kernel space: study on metabolomic characterization of progression of multiple sclerosis. Smolinska A, Blanchet L, Coulier L, Ampt KA, Luider T, Hintzen RQ, Wijmenga SS, Buydens LM. PLoS One. 2012;7(6):e38163. doi: 10.1371/journal.pone.0038163. Epub 2012 Jun 8.

Interstitial lung damage due to cocaine abuse: pathogenesis, pharmacogenomics and therapy. Drent M, Wijnen P, Bast A. Curr Med Chem. 2012 Nov 1;19(33):5607-11.

Knowledge, attitudes and preferences regarding genetic testing for smoking cessation. A cross-sectional survey among Dutch smokers. Quaak M, Smerecnik C, van Schooten FJ, de Vries H, van Schayck CP. BMJ Open. 2012 Jan 5;2:e000321. doi: 10.1136/bmjopen-2011-000321. Print 2012.

Maternal intake of quercetin during gestation alters ex vivo benzo[a]pyrene metabolism and DNA adduct formation in adult offspring. Vanhees K, van Schooten FJ, Moonen EJ, Maas LM, van Waalwijk van Doorn-Khosrovani SB, Godschalk RW. Mutagenesis. 2012 Jul;27(4):445-51. doi: 10.1093/mutage/ges002. Epub 2012 Feb 14.

Measures of combined antioxidant and pro-oxidant exposures and risk of overall and advanced stage prostate cancer. Geybels MS, Verhage BA, van Schooten FJ, van den Brandt PA. Ann Epidemiol. 2012 Nov;22(11):814-20. doi: 10.1016/j.annepidem.2012.07.010. Epub 2012 Sep 15.

Neutrophils augment LPS-mediated pro-inflammatory signaling in human lung epithelial cells. Boots AW, Gerloff K, Bartholomé R, van Berlo D, Ledermann K, Haenen GR, Bast A, van Schooten FJ, Albrecht C, Schins RP. Biochim Biophys Acta. 2012 Jul;1823(7):1151-62. doi: 10.1016/j.bbamcr.2012.04.012. Epub 2012 May 1.

NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a review. Smolinska A, Blanchet L, Buydens LM, Wijmenga SS. Anal Chim Acta. 2012 Oct 31;750:82-97. doi: 10.1016/j.aca.2012.05.049. Epub 2012 Jun 9.

Non-alcoholic steatohepatitis: A non-invasive diagnosis by analysis of exhaled breath. Verdam FJ, Dallinga JW, Driessen A, Jonge CD, Moonen EJ, van Berkel JB, Luijk J, Bouvy ND, Buurman WA, Rensen SS, Greve JW, Schooten FJ. J Hepatol. 2012 Nov 7. doi:pii: S0168-8278(12)00832-X. 10.1016/j.jhep.2012.10.030. [Epub ahead of print]

Of reductionism and the pendulum swing: connecting toxicology and human health. Hanekamp JC, Bast A, Kwakman JH. Dose Response. 2012;10(2):155-76. doi: 10.2203/dose-response.11-018.Hanekamp. Epub 2011 Jul 12.

Optimizing the bioactive potential of wheat bran by processing. Mateo Anson N, Hemery YM, Bast A, Haenen GR. Food Funct. 2012 Apr;3(4):362-75. doi: 10.1039/c2fo10241b. Epub 2012 Feb 15. Review. No abstract available.

Organ specificity of beta-carotene induced lung gene-expression changes in Bcmo1(-/-) mice. van Helden YG, Godschalk RW, van Schooten FJ, Keijer J. Mol Nutr Food Res. 2012 Dec 2. doi: 10.1002/mnfr.201200277. [Epub ahead of print]

Oral lixivaptan effectively increases serum sodium concentrations in outpatients with euvolemic hyponatremia. Abraham WT, Decaux G, Josiassen RC, Yagil Y, Kopyt N, Thacker HP, Mannelli M, Bichet DG, Orlandi C; HARMONY Study Group. Kidney Int. 2012 Dec;82(11):1215-22. doi: 10.1038/ki.2012.274. Epub 2012 Aug 29.

Pleiotropic-acting nutrients require integrative investigational approaches: the example of flavonoids. Weseler AR, Bast A. J Agric Food Chem. 2012 Sep 12;60(36):8941-6. doi: 10.1021/jf3000373. Epub 2012 Apr 9.

Prediction of asthma exacerbations in children: results of a one-year prospective study. Robroeks CM, van Vliet D, Jöbsis Q, Braekers R, Rijkers GT, Wodzig WK, Bast A, Zimmermann LJ, Dompeling E. Clin Exp Allergy. 2012 May;42(5):792-8. doi: 10.1111/j.1365-2222.2012.03992.x.

Simultaneous analysis of plasma and CSF by NMR and hierarchical models fusion. Smolinska A, Posma JM, Blanchet L, Ampt KA, Attali A, Tuinstra T, Luider T, Doskocz M, Michiels PJ, Girard FC, Buydens LM, Wijmenga SS. Anal Bioanal Chem. 2012 May;403(4):947-59. doi: 10.1007/s00216-012-5871-4. Epub 2012 Mar 7.

Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice S Paglialunga, B van Bree, M Bosma, MP Valdecantos, E Amengual-Cladera, JA Jörgensen, D van Beurden, GJM den Hartog, DM Ouwens, JJ Briedé, P Schrauwen, J Hoeks Diabetologia DOI 10.1007/s00125-012-2626-x Springer Verlag 2012

Telomere length, oxidative stress, and antioxidant status in elderly men in Zutphen and Crete. de Vos-Houben JM, Ottenheim NR, Kafatos A, Buijsse B, Hageman GJ, Kromhout D, Giltay EJ. Mech Ageing Dev. 2012 Jun;133(6):373-7. doi: 10.1016/j.mad.2012.04.003. Epub 2012 Apr 25.

The anti-inflammatory effect of lycopene complements the antioxidant action of ascorbic acid and a-tocopherol. Hazewindus M, Haenen GRMM, Weseler AR, Bast A. Food Chemistry 132 (2): 954-958 (2012)

The cholesterol derivative 27-hydroxycholesterol reduces steatohepatitis in mice. Bieghs V, Hendrikx T, van Gorp PJ, Verheyen F, Guichot YD, Walenbergh SM, Jeurissen ML, Gijbels M, Rensen SS, Bast A, Plat J, Kalhan SC, Koek GH, Leitersdorf E, Hofker MH, Lütjohann D, Shiri-Sverdlov R. Gastroenterology. 2013 Jan;144(1):167-178.e1. doi: 10.1053/j.gastro.2012.09.062. Epub 2012 Oct 3.

The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model: Theoretical and Epidemiological Considerations. van den Heuvel MG, Bast A, Ambergen AW, van der Hulst RR. J Transplant. 2012;2012:504081. doi: 10.1155/2012/504081. Epub 2012 May 9.

The anti-inflammatory effect of lycopene complements the antioxidant action of ascorbic acid and a-tocopherol. Ezzat T, van den Broek MA, Davies N, Dejong CH, Bast A, Malagó M, Dhar DK, Hazewindus M, Haenen GRMM, Weseler AR, Bast A. Food Chemistry 132 (2): 954-958 (2012)

The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats. Ezzat T, van den Broek MA, Davies N, Dejong CH, Bast A, Malagó M, Dhar DK, Olde Damink SW. J Surg Oncol. 106 (1), 72-78 (2012)

The impact of delayed storage on the measured proteome and metabolome of human cerebrospinal fluid. Rosenling T, Stoop MP, Smolinska A, Muilwijk B, Coulier L, Shi S, Dane A, Christin C, Suits F, Horvatovich PL, Wijmenga SS, Buydens LM, Vreeken R, Hankemeier T, van Gool AJ, Luider TM, Bischoff R. Clin Chem. 2011 Dec;57(12):1703-11. doi: 10.1373/clinchem.2011.167601. Epub 2011 Oct 13.

The P2X7 loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels. Wesselius A, Bours MJ, Arts IC, Theunisz EH, Geusens P, Dagnelie PC. BMC Immunol. 2012 Dec 4;13:64. doi: 10.1186/1471-2172-13-64.

The role of antioxidants in ischaemia-reperfusion in a human DIEP flap model. van den Heuvel MG, Bast A, Haenen GR, Ambergen AW, Mermans JF, van der Hulst RR. J Plast Reconstr Aesthet Surg. 2012 Dec;65(12):1706-11. doi: 10.1016/j.bjps.2012.06.010. Epub 2012 Jul 11.

The versatile use of exhaled volatile organic compounds in human health and disease. Boots AW, van Berkel JJ, Dallinga JW, Smolinska A, Wouters EF, van Schooten FJ. J Breath Res. 2012 Jun;6(2):027108. doi: 10.1088/1752-7155/6/2/027108. Epub 2012 May 23. Review.

Variation in PAH-related DNA adduct levels among non-smokers: The role of multiple genetic polymorphisms and nucleotide excision repair phenotype. Etemadi A, Islami F, Phillips DH, Godschalk R, Golozar A, Kamangar F, Malekshah AF, Pourshams A, Elahi S, Ghojaghi F, Strickland PT, Taylor PR, Boffetta P, Abnet CC, Dawsey SM, Malekzadeh R, van Schooten FJ. Int J Cancer. 2012 Nov 23. doi: 10.1002/ijc.27953. [Epub ahead of print]

Wheat Aleurone: Separation, composition, health aspects and potential food use Fred Brouns, Youna Hemery, Ruth Price and Nuria Mateo Anson Food Science and Nutrition, 52:553-568(2012)

W II publications.

Oxidativen Stress und Antioxidantien bei Interstitiellen Lungenerkrankungen A.R. Weseler, A. Bast Apotheken Magazin 1-2, 8-13 (2012)

Therapeutic options for ILD: Food or pharma? A. Bast, ILD Care Today 10, 32-35 (2012).

Management van longfibrose: Stand van zaken. M. Drent, A. Bast Therapie on Line (www.farmacotherapie.org) November, 1-19 (2012)

Theses

Assessment of genetic variation as a predictor of smoking cessation success. Marieke Quaak. Promotores: FJ van Schooten en O van Schayck

Effect of flavonoidson fetal programming.Implications for cancer susceptibility. Kimberly Vanhees. Promotor: FJ van Schooten

Hypoxia, oxidative stress, and benzo[a]pyre3ne induced carcinogenesis. Marten Schults. Promotor: FJ van Schooten

Paternal impact on genetic integrity in newborns Joost Linschooten. Promotor: FJ van Schooten

Tomatoes as functional food. Merel Hazewindus. Promotor: A Bast

Bookchapters

A.R. Weseler en A. Bast. Effects of flavonoids on the vascular endothelium: What is known and what is next? In: flavonoids and related compounds. Bioavailability and function. Eds. J.P.E. Spencer, A. Crozier. CRC Press. Pp. 309-330 (2012).