Department of Pharmacology & Toxicology

Publications 2011

Coolen EJCM, Arts ICW, Bekers O, Vervaet C, Bast A, Dagnelie PC. Oral bioavailability of ATP after prolonged administration. Br. J. Nutr. 105(3), 357-366 (2011).

Jacobs H, Bast A, Peters GJ, van der Vijgh WJF, Haenen GRMM. The semisynthetic flavonoid monoHER sensitises human soft tissue sarcoma cells to doxorubicin-induced apoptosis via inhibition of nuclear factor-κB. Br. J. Cancer. 104(3), 437-440 (2011).

Jacobs H, Peters R, den Hartog GJ, van der Vijgh WJ, Bast A, Haenen GR. Identification of the metabolites of the antioxidant flavonoid 7-mono-O-({beta}-hydroxyethyl)-rutoside in mice. Drug Metab Dispos. 39(5): 750-756 (2011)

Boots AW, Drent M, de Boer VC, Bast A, Haenen GRMM Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis. Clin. Nutr. 30(4), 506-512 (2011).

Koek GH, Liedorp PR, Bast A. The role of oxidative stress in non-alcoholic steatohepatitis. Clin. Chim. Acta 412, 1297-1305 (2011).

Jacobs H, Moalin M, van Gisbergen MW, Bast A, van der Vijgh WJF, Haenen GRMM An essential difference in the reactivity of the glutathione adducts of the structurally closely related flavonoids monoHER and quercetin. Free Radic. Biol. Med. 15 (11), 2118-2123 (2011).

Jacobs H, Koek GH, Peters R, Moalin M, Tack J, van der Vijgh WJ, Bast A, Haenen GRMM. Differences in pharmacological activities of the antioxidant flavonoid monoHER in humans and mice are caused by variations in its metabolic profile. Clin. Pharmacol. Ther. 90 (6), 852-859 (2011).

Moalin M, Strijdonck GP, Beckers M, Hageman G, Borm P, Bast A, Haenen GRMM. A planar conformation and the hydroxyl groups in the B and C rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives. Molecules 16 (11), 9636-9650 (2011).

Weseler AR, Ruijters EJ, Drittij-Reijnders MJ, Reesink KD, Haenen GRMM, Bast A. Pleiotropic benefit of monomeric and oligomeric flavanols on vascular health – a randomized controlled clinical pilot study. PLos One 6 (12), e28460 (2011)

Snoeijs MG, Vaahtera L, de Vries EE, Schurink GW, Haenen GR, Peutz-Kootstra, CJ, Buurman WA, van Heurn LW, Parkkinen J. Addition of a water-soluble profofol formulation to preservation solution in experimental kidney transplantation.Reprod Toxicol. 2011 Jul;32(1):106-11. Epub 2011 May 20

Snoeijs MG, van Bijnen A, Swennen E, Haenen GR, Roberts LJ2nd, Christiaans MH, Peppelenbosch AG, Buurman WA, Ernest van Heurn LW. Tubular epithelial injury and inflammation after ischemia and reprfusion in human kidney transplantation.Ann Surg. 2011 Mar;253(3):598-604

Mateo Ansón N, Aura AM, Selinheimo E, Mattila I, Poutanen K, van den Berg R, Havenaar R, Bast A, Haenen GR. Bioprocessing of wheat bran in whole wheat bread increases the bioavailability of phenolic acids in men and exerts anti-inflammatory effects ex vivo. J Nutr. 2011 Jan;141(1):137-43. Epub 2010 Nov 24.

Gerloff K, Albrecht C, Boots AW, Förster I, Schins RP. Particles which may occur in food or foor packaging can exert cytotoxicity and (oxidative) DNA damage in target cells of the human intestine. Nanotoxicology. 2011 Jun;5(2):282-3. Epub 2010 Nov 1.

De Vogel S, Wouters KA, Gottschalk RW, Van Schooten FJ, De Goeij AF, De Bruïne AP, Goldbohm RA, Van den Brandt PA, Van Engeland M, Weijenberg MP. Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer. Cancer Causes Control 22: 1-12, 2011.

Van Helden YG, Godschalk RW, Swarts HJ, Hollman PC, Van Schooten FJ, Keijer J. Beta-carotene affects gene expression in lungs of male and female Bcmo1 (-/-) mice in opposite directions. Cell Mol Life Sci 68: 489-504, 2011.

Vanhees K, de Bock L, Godschalk RW, Van Schooten FJ, Van Waalwijk van Doorn-Khosrovani SB. Prenatal exposure to flavonoids: implication for cancer risk. Toxicol Sci 120: 59-67, 2011.

Bongaerts BW, De Goeij AF, Wouters KA, Van Engeland M, Gottschalk RW, Van Schooten FJ, Goldbohm RA, Van den Brandt PA, Weijenberg MP. Alcohol consumption, alcohol dehydrogenase 1C (ADH1C) genotype, and risk of colorectal cancer in the Netherlands Cohort Study on diet and cancer. Alcohol 45: 217-25, 2011.

Vanhees K, Coort S, Ruijters EJ, Godschalk RW, Van Schooten FJ, van Doorn-Khosrovani SB. Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage. FASEB J 25: 797-807, 2011.

Wessels A, Van Berlo D, Boots AW, Gerloff K, Scherbart AM, Cassee FR, Gerlofs-Nijland ME, Van Schooten FJ, Albrecht C, Schins RP. Oxidative stress and DNA damage responses in rat and mouse lung to inhaled carbon nanoparticles. Nanotoxicology 5: 66-78, 2011.

Verhofstad N, Van Oostrom CT, Zwart E, Maas LM, Van Benthem J, Van Schooten FJ, Van Steeg H, Godschalk RW. Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells. Toxicol Sci 119: 218-23, 2011.

Smerecnik C, Quaak M, Van Schayck CP, Van Schooten FJ, De Vries H. Are smokers interested in genetic testing for smoking addiction? A socio-cognitive approach. Psychology & Health 26: 1099-112, 2011.

Halappanavar S, Wu D, Williams A, Kuo B, Godschalk RW, Van Schooten FJ, Yauk CL. Pulmonary gene and microRNA expression changes in mice exposed to benzo(a)pyrene by oral gavage. Toxicology 285: 133-41, 2011.

Linschooten J, Laubenthal J, Cemeli E, Baumgartner A, Anderson D, Sipinen V, Brunborg G, Haenen G, Ethenou E, Briedé J, Van Schooten FJ, Godschalk R. Incomplete protection of genetic integrity of mature spermatozoa against oxidative stress. Reproductive Toxicology 32: 106-11, 2011.

Van Helden YG, Godschalk RW, Von Lintig J, Lietz G, Landrier JF, Luisa Bonet M, Van Schooten FJ, Keijer J. Gene expression response of mouse lung, liver and white adipose tissue to β-carotene supplementation, knockout of Bcmo1 and sex. Mol Nutr Food Res 55: 1466-74, 2011.

Scherbart AM, Langer J, Bushmelev A, van Berlo D, Haberzettl P, van Schooten FJ, Schmidt AM, Rose CR, Schins RP, Albrecht C. Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms. Part Fibre Toxicol 8(1): 31, 2011.

Vanhees K, Sanders A, Barjesteh van Waalwijk van Doorn-Khosrovani S, Godschalk RW, Van Schooten FJ. Maternal quercetin intake during pregnancy results in adapted iron homeostasis at adulthood. Toxicology 290; 350-358, 2011.

Ketelslegers HB, Godschalk RW, Gottschalk RW, Knaapen AM, Koppen G, Schoeters G, Baeyens WF, Nelen V, Geraedts JP, van Delft JH, Kleinjans JC, van Larebeke NA. Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study. Environ Health. 2011;10:85.

Al-Salmani K, Abbas HH, Schulpen S, Karbaschi M, Abdalla I, Bowman KJ, So KK, Evans MD, Jones GD, Godschalk RW, Cooke MS. Simplified method for the collection, storage, and comet assay analysis of DNA damage in whole blood. Free Radic Biol Med. 2011;51(3):719-25.

Nielsen TS, Purup S, Wärri A, Godschalk RW, Hilakivi-Clarke L. Effects of maternal exposure to cow’s milk high or low in isoflavones on carcinogen-induces mammary tumorigenesis among rat offspring. Cancer Prev Res (Phila). 2011;4(5):694-701.

Houben JMJ, Giltay EJ, Rius-Ottenheim N, Hageman GJ, Kromhout D. Telomere length and mortality in elderly men: the Zutphen Elderly Study. Journal of Gerontology: Biological Sciences, 2011;66(1):38-44.

Mercken EM, Hageman GJ, Langen RC, Wouters EF, Schols AM, Decreased exercise-induced expression of NF-kB reulated genes in muscle of COPD patients. Chest, 2011 Feb;139(2):337-46

Theses 2011

Coolen E.
Kinetics and effects of orally Administered ATP; thesis defense 11-05-2011, UM. Promotores: Prof. dr. A. Bast; prof. dr. M.A. Cohen Stuart Co-promotores: Dr. Ir. P.C. Dagnelie; Dr. Ir. I.C.W. Arts

Jacobs H.
The antioxidant flavonoid 7-mono-O-(β-hydroxyethyl)-rutoside; thesis defense 01-07-2011, UM. Promotor: Prof. dr. A. Bast. Co-promotores: Dr. G. Haenen; Emer. Prof. Dr. Wim van der Vijgh

Houben J.
Chronic oxidative stress and PARP enzymes in telomere length regulation; thesis defense 21-01-2011, UM Promotores: prof.dr. F.J. van Schooten; prof.dr. E.F.M. Wouters, Co-promotor: dr.ir. G.J. Hageman

Kelder T.
Exploratory pathway analysis; thesis defense 08-07-2011, UM. Promotor: prof.dr. F.J. van Schooten; Co-promotor: dr.ir. C.T.A. Evelo