Department of Pharmacology & Toxicology

Publications 2010

Publications in peer reviewed journals 2010:

Bongaerts BW, de Goeij AF, Wouters KA, van Engeland M, Gottschalk RW, Van Schooten FJ, Goldbohm RA, van den Brandt PA, Weijenberg MP. Alcohol consumption, alcohol dehydrogenase 1C (ADH1C) genotype, and risk of colorectal cancer in the Netherlands Cohort Study on diet and cancer. Alcohol. 2010 Dec 14.

Dallinga JW, Robroeks CM, van Berkel JJ, Moonen EJ, Godschalk RW, Jöbsis Q, Dompeling E, Wouters EF, van Schooten FJ. Volatile organic compounds in exhaled breath as a diagnostic tool for asthma in children. Clin Exp Allergy. 2010 Jan;40(1):68-76.

De Vogel S, Wouters KA, Gottschalk RW, van Schooten FJ, de Goeij AF, de Bruïne AP, Goldbohm RA, van den Brandt PA, van Engeland M, Weijenberg MP. Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer. Cancer Causes Control. 2011 Jan;22(1):1-12.

Giltay EJ, Hageman GJ, Kromhout D. Spurious association between telomere length reduction over time and baseline telomere length. Int J Epidemiol. 2010 Dec 12.

Güngör N, Pennings JL, Knaapen AM, Chiu RK, Peluso M, Godschalk RW, Van Schooten FJ. Transcriptional profiling of the acute pulmonary inflammatory response induced by LPS: role of neutrophils. Respir Res. 2010 Feb 25;11:24.

Güngör N, Haegens A, Knaapen AM, Godschalk RW, Chiu RK, Wouters EF, van Schooten FJ. Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo. Mutagenesis. 2010 Jan;25(1):77-82.

Güngör N, Knaapen AM, Munnia A, Peluso M, Haenen GR, Chiu RK, Godschalk RW, van Schooten FJ. Genotoxic effects of neutrophils and hypochlorous acid. Mutagenesis. 2010 Mar;25(2):149-54.

Langie SA, Wilms LC, Hämäläinen S, Kleinjans JC, Godschalk RW, van Schooten FJ. Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors. Br J Nutr. 2010 Feb;103(4):490-501.

Langie SA, Kowalczyk P, Tudek B, Zabielski R, Dziaman T, Oliński R, van Schooten FJ, Godschalk RW. The effect of oxidative stress on nucleotide-excision repair in colon tissue of newborn piglets. Mutat Res. 2010 Jan;695(1-2):75-80.

Langie SA, Wilms LC, Hämäläinen S, Kleinjans JC, Godschalk RW, van Schooten FJ. Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors. Br J Nutr. 2010 Feb;103(4):490-501

Luijten M, van Beelen VA, Verhoef A, Renkens MF, van Herwijnen MH, Westerman A, van Schooten FJ, Pennings JL, Piersma AH. Transcriptomics analysis of retinoic acid embryotoxicity in rat postimplantation whole embryo culture. Reprod Toxicol. 2010 Sep;30(2):333-40.

Robroeks CM, van Berkel JJ, Dallinga JW, Jöbsis Q, Zimmermann LJ, Hendriks HJ, Wouters MF, van der Grinten CP, van de Kant KD, van Schooten FJ, Dompeling E. Metabolomics of volatile organic compounds in cystic fibrosis patients and controls. Pediatr Res. 2010 Jul;68(1):75-80.

Schults MA, Timmermans L, Godschalk RW, Theys J, Wouters BG, van Schooten FJ, Chiu RK. Diminished carcinogen detoxification is a novel mechanism for hypoxia-inducible factor 1-mediated genetic instability. J Biol Chem. 2010 May 7;285(19):14558-64.

Sipinen V, Laubenthal J, Baumgartner A, Cemeli E, Linschooten JO, Godschalk RW, Van Schooten FJ, Anderson D, Brunborg G. In vitro evaluation of baseline and induced DNA damage in human sperm exposed to benzo[a]pyrene or its metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide, using the comet assay. Mutagenesis. 2010 Jul;25(4):417-25. Epub 2010 May 20.

Theunissen PT, Schulpen SH, van Dartel DA, Hermsen SA, van Schooten FJ, Piersma AH. An abbreviated protocol for multilineage neural differentiation of murine embryonic stem cells and its perturbation by methyl mercury. Reprod Toxicol. 2010 Jul;29(4):383-92.

Van Berkel JJ, Dallinga JW, Möller GM, Godschalk RW, Moonen EJ, Wouters EF, Van Schooten FJ. A profile of volatile organic compounds in breath discriminates COPD patients from controls. Respir Med. 2010 Apr;104(4):557-63.

Van Berlo D, Knaapen AM, van Schooten FJ, Schins RP, Albrecht C. NF-kappaB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells. Part Fibre Toxicol. 2010 May 21;7:13.

Van Berlo D, Albrecht C, Knaapen AM, Cassee FR, Gerlofs-Nijland ME, Kooter IM, Palomero-Gallagher N, Bidmon HJ, van Schooten FJ, Krutmann J, Schins RP. Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Arch Toxicol. 2010 Jul;84(7):553-62.

Van Berlo D, Wessels A, Boots AW, Wilhelmi V, Scherbart AM, Gerloff K, van Schooten FJ, Albrecht C, Schins RP. Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles. Free Radic Biol Med. 2010 Dec 1;49(11):1685-93

Van Dartel DA, Pennings JL, de la Fonteyne LJ, van Herwijnen MH, van Delft JH, van Schooten FJ, Piersma AH. Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes. Toxicol Sci. 2010 Jul;116(1):130-9.

Van Dartel DA, Pennings JL, de la Fonteyne LJ, Brauers KJ, Claessen S, van Delft JH, Kleinjans JC, Piersma AH. Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures. Toxicol Appl Pharmacol. 2010 Dec 28. pagenummers and volume missing

Van Dartel DA, Pennings JL, van Schooten FJ, Piersma AH. Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells. Toxicol Appl Pharmacol. 2010 Mar 15;243(3):420-8.

Vanhees K, Coort S, Ruijters EJ, Godschalk RW, van Schooten FJ, van Doorn-Khosrovani SB. Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage. FASEB J. 2010 Nov 3.

Vanhees K, de Bock L, Godschalk RW, van Schooten FJ, van Waalwijk van Doorn-Khosrovani SB. Prenatal exposure to flavonoids: implication for cancer risk. Toxicol Sci. 2010

Vanhees K, de Bock L, van Schooten FJ, Barjesteh van Waalwijk van Doorn-Khosrovani S. The role of estrogenic compounds in the etiology of pediatric leukemia. Leuk Res. 2009 Nov;33(11):e210-1. Epub 2009 Jul 4.

Van Helden YG, Godschalk RW, Heil SG, Bunschoten A, Hessel S, Amengual J, Bonet ML, von Lintig J, van Schooten FJ, Keijer J. Downregulation of Fzd6 and Cthrc1 and upregulation of olfactory receptors and protocadherins by dietary beta-carotene in lungs of Bcmo1-/- mice. Carcinogenesis. 2010 Aug;31(8):1329-37.

Van Helden YG, Heil SG, van Schooten FJ, Kramer E, Hessel S, Amengual J, Ribot J, Teerds K, Wyss A, Lietz G, Bonet ML, von Lintig J, Godschalk RW, Keijer J. Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene. Cell Mol Life Sci. 2010 Jun;67(12):2039-56.

Van Helden YG, Keijer J, Heil SG, Picó C, Palou A, Oliver P, Munnia A, Briedé JJ, Peluso M, Franssen-van Hal NL, van Schooten FJ, Godschalk RW. Beta-carotene affects oxidative stress-related DNA damage in lung epithelial cells and in ferret lung. Carcinogenesis. 2009 Dec;30(12):2070-6.

Verhofstad N, van Oostrom CT, Zwart E, Maas LM, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW. Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells. Toxicol Sci. 2011 Jan;119(1):218-23.

Verhofstad N, van Oostrom CT, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW. DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo(a)pyrene. Environ Mol Mutagen. 2010 Mar;51(2):123-9.

Verhofstad N, Pennings JL, van Oostrom CT, van Benthem J, van Schooten FJ, van Steeg H, Godschalk RW. Benzo(a)pyrene induces similar gene expression changes in testis of DNA repair proficient and deficient mice. BMC Genomics. 2010 May 26;11:333

Weseler AR, Bast A. Oxidative stress and vascular function: implications for pharmacologic treatments. Curr Hypertens Rep. 2010;12(3):154-161.

Swennen EL, Ummels V, Buss I, Jaehde U, Bast A, Dagnelie PC. ATP sensitizes H460 lung carcinoma cells to cisplatin-induced apoptosis. Chem Biol Interact. 2010;184(3):338-345.

Mateo Anson N, Aura AM, Selinheimo E, Mattila I, Poutanen K, van den Berg R, Havenaar R, Bast A, Haenen GR. Bioprocessing of Wheat Bran in Whole Wheat Bread Increases the Bioavailability of Phenolic Acids in Men and Exerts Antiinflammatory Effects ex Vivo. J Nutr. 2010.

Jacobs H, Moalin M, Bast A, van der Vijgh WJ, Haenen GR. An essential difference between the flavonoids monoHER and quercetin in their interplay with the endogenous antioxidant network. PLoS One. 2010;5(11):e13880.

Hamer HM, Jonkers DM, Vanhoutvin SA, Troost FJ, Rijkers G, de Bruine A, Bast A, Venema K, Brummer RJ. Effect of butyrate enemas on inflammation and antioxidant status in the colonic mucosa of patients with ulcerative colitis in remission. Clin Nutr. 2010;29(6):738-744.

Geraets L, Haegens A, Weseler AR, Brauers K, Vernooy JH, Wouters EF, Bast A, Hageman GJ. Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine. Eur J Pharmacol. 2010;629(1-3):132-139.

Den Hartog GJ, Boots AW, Adam-Perrot A, Brouns F, Verkooijen IW, Weseler AR, Haenen GR, Bast A. Erythritol is a sweet antioxidant. Nutrition. 2010;26(4):449-458.

Coolen EJ, Arts IC, Bekers O, Vervaet C, Bast A, Dagnelie PC. Oral bioavailability of ATP after prolonged administration. Br J Nutr. 2010:1-9.

Bieghs V, Vlassaks E, Custers A, Van Gorp PJ, Gijbels MJ, Bast A, Bekers O, Zimmermann LJ, Lutjohann D, Voncken JW, Gavilanes AW, Kramer BW, Shiri-Sverdlov R. Chorioamnionitis induced hepatic inflammation and disturbed lipid metabolism in fetal sheep. Pediatr Res. 2010.

Beljaars CP, Balk JM, Bast A, Haenen GR. Prevention of a systematic underestimation of antioxidant activity in competition assays. The impact of unspecific reactions of the reactive species. Biochem Biophys Res Commun. 2010;392(3):346-350.

Bast A, Weseler AR, Haenen GR, den Hartog GJ. Oxidative stress and antioxidants in interstitial lung disease. Curr Opin Pulm Med. 2010;16(5):516-520.

Bartholome R, Haenen G, Hollman CH, Bast A, Dagnelie PC, Roos D, Keijer J, Kroon PA, Needs PW, Arts CW. Deconjugation kinetics of glucuronidated phase II flavonoid metabolites by beta-glucuronidase from neutrophils. Drug Metab Pharmacokinet. 2010;25(4):379-387.

Mensink RP, de Jong A, Lütjohann D, Haenen GR, Plat J. Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d. American Journal Clin Nutr. 2010 Jul; 92(1):24-33.

Wijnen PA, Linssen CF, Haenen GR, Bekers O, Drent M. Variant VKORC1 and CYP2C9 alleles in patients with diffuse alveolar hemorrhage caused by oral anticoagulants. Molecular Diagn.Ther. 2010 Feb; 1;14(1):23-30.

Other publications 2010

Bast A. De dosis telt. Ned. Tijdschr. Geneesk. 2010;154: B607.

Bast A. Onzinnige biofilie. Ned. Tijdschr. Geneesk. 2010; 154: B609.

Bast A. Duscalculie en dyslexie gevaar voor de farmacotherapie. Ned. Tijdschr. Geneesk. 2010; 154: B611.

Bast A. Het succes van de medicijnman. Ned. Tijdschr. Geneesk. 2010; 154: B613

PhD-Theses 2010:

Joep van Berkel; There’s something in the air. Volatile organic compounds in exhaled breath in pulmonary diseases.

Damiën van Berlo; The elusive particle hazard. Inflammatory and oxidative stress responses

Yvonne van Helden; Molecular mechanisms of beta-carotene action in the lung

Nicole Verhofstad; Paternal exposure to benzo(a)pyrene; a genetic risk in offspring ?

Jiska Balk; Antioxidant activity: from model to man.

Shufan Qi; The Specific Role of Superoxide Radicals in Fibrosis.

Nuria Mateo Anson; Bioactive compounds in whole grain wheat for evaluation.